Friday, September 17, 2021
petyaariad1

Nephritis In Dogs

on

Ajaykumarpala
Myself a Veterinary student. Hoping to be the best vet.

Follow US On

petyaariad2

NEPHRITIS (BRIGHTS DISEASE)

Definition

IS DEFINED AS INFLAMMATION OF KIDNEY ( RENAL CELLS ) CHARACTERISED BY RENAL COLIC AND WHICH RESULTS IN DELETERIOUS EFFECT ON HEALTH OF ANIMAL.
DOG, ONCE EFFECTED WITH NEPHRITIS, SEQUELAE IS DEATH.

Nephritis In Dogs

YOUR URINE VOLUME NOT ONLY ESTIMATES YOUR WATER INTAKE BUT ALSO KIDNEY FUNCTION

ONCE IT GET DIFFICULT TO URINATE , NEEDS HIGH CARE AND ATTENTION
KEEP IN MIND THAT MALE USED TO URINATE BY LIFTQING ONE OF THE HIND LIMB AND PREFER TO URINATE IN A JET FASHION OVER ANY TREE WALL BITCHES URINATE IN SQUATTING POSTURE

Classification

IT IS OF TWO TYPES

  • SUPPURATIVE: PYEMIC- AND PYELO-NEPHRITIS
  • NON SUPPURATIVE: GLOMERULAR NEPHRITIS, TUBULAR AND INTERSTITIAL NEPHRITIS

IN CASE OF OR PETS INTERSTITIAL AND GLOMERULAR ARE COMMONLY SEEN

ETIOLOGY :

Nephritis In Dogs
  •  FOOD AND WATER QUALITY
  • BACTERIA : E.COLI, LEPTOSPIRA
  • VIRUS: ICH
  • PARASITE: DIACTOPHYMA RENALE
  • OTHERS: METRITIS, PYOMETRA, BRONCHOPNEUMONIA, CYSTITIS, PROSTATITIS, CHRONIC PERITONITIS, AND CHRONIC INFECTIONS.
  • DRUGS: AMINOGLYCOSIDES, NEPHROTOXIC AGENTS, LEAD, ARSENATE, SULPHONAMIDE, MERCURY, AMPHOTERICIN B, AND PARACETAMOL

PATHOGENESIS :

GLOMERULAR NEPHRITIS:

  • INFECTION MAY SPREAD FROM DESCENDING AND ASCENDING SITE
  • STASIS OF URINE RESULTS IN ACCUMULATION OF MICROBES ALONG URINARY TRACT
  • THROUGH EMBOLI OR BLOOD BORNE , IT MAY RESULTS IN OCCURENCE OF
  • MAYBE DUE TO AUTOIMMUNE ACTIVITY

INTERSTITIAL NEPHRITIS:

  • INTERSTITIAL NEPHRITIS: VERY COMMON
  • CHRONIC FORM IS ALWAYS SEQULAE TO ACUTE FORM
  • PATHOGENESIS: PERIVASCULAR PERIGLOMERULAR INTERTUBULAR INFILTRATIONS,
  • KIDNEY PARENCHYMA UNDERGOES INFLAMMATORY CHANGES,
  • BLOCKS TUBULES OF KIDNEY WITH CELLULAR INFILTRATIONS
Nephritis In Dogs

CLINICAL SIGNS :

GLOMERULAR NEPHRITIS:

  • INFLAMMATION OF GLOMERULI LEADS TO CHRONIC RENAL FAILURE.
  • DULL AND DEPRESSED
  • SLIGHT RISE OF TEMPERATURE.
  • POLYDISPIA
  • PUFFY EYELIDS
  • MUSCLE WASTAGE
  • PROTEINURIA
  • VOMITING
  • AZOTEMIA
  • DRY SKIN COAT

INTERSTITIAL NEPHRITIS:

  • LACK OF APPETITE
  • POLYUREA AND POLYDISPIA
  • BREATH IS UNPLEASANT
  • TEETH, GUM, TONGUE COATED WITH REDDISH BROWN SCUM
  • ARCHING OF BACK AND STIFF GAIT
  • LUMBAR REGION PAIN
  • PULSE IS QUICK BOUNDING
  • CHRONIC CASES IT BECOME THIN AND EMACIATED
  • SIGNS OF DEHYDRATION
  • OCCASIONAL VOMITION
  • SIGNS OF URAEMIA
Nephritis In Dogs

DIAGNOSIS:

GLOMERULAR NEPHRITIS:

  • examination of Urine
  • PROTEINURIA
  • Proper history
  • Hematology: HYOPROTEINEMIA DUE TO HYPOALBUMINAEMIA, HYPERPROTEINAEMIA DUE TO HYPERGLOBINAEMIA, NORMOCYTIC NORMOCHROMIC ANAEMIA
  • BIOCHEMISTRY : HYPERCHOLESTEROLEMIA, HYPERPHOSPHATEMIA
  • AZOTEMIA
  • URINE STUDY : PROTEINURIA
  • PROTEIN INDEX : URINE = PROTEIN/ CREATININE RATIO>1 UPL = 1.42 + 22.12 × UP/C
  • RENAL BIOPSY
Nephritis In Dogs

INTERSTITIAL NEPHRITIS:

  • POLYUREA AND POLY DYSPIA
  • ACUTE: URINE HAVE HIGH SPECIFIC GRAVITY, ALBUMIN, RENAL EPITHELIAL CELLS, WBC, RBC, CASTS IN URINE.
  • CHRONIC: LOW SPECIFIC GRAVITY, LESS CELLULAR DEPOSITION.

DIFFERENTIAL DIAGNOSIS:

GLOMERULAR NEPHRITIS:

  • AMYLOIDOSIS: AMYLOID DEPOSITS WILL TAKE GREENISH APPEARANCE UPON STAINED WITH CONGORED
  • NEPHRITIS : LUMOY BUMPY DEPOSITS OF Immuno Globulins & COMPLEMENTS MAY BE OBSERVED PROLIFERATION OF MESANGIAL CELLS HYPERCELLULARITY IN BASEMENT MEMBRANE GLOMERULUS SCLEROSIS

INTERSTITIAL NEPHRITIS:

Chronic Interstitial Diabetes mellitusDiabetes insipidus
Kidney is affectedIslets of pancreaspost. pituitary gland
specific gravity is lowhighlow
Casts- very fewnilnil
Sugar- nilpresentnil
Uraemia- presentnilnil

Differentiation between glomerular and interstitial nephritis:

Nephritis In Dogs
ParameterGlomerular Interstitial
Urine VolumeLowMore
Specific Gravitymorelow
Urinary sedimentcastsfew casts and WBC
Protein & UreaMoreLow
AnemiaModerateHigh

TREATMENT:

GLOMERULAR NEPHRITIS:

  • CASES WITHOUT NEPHROTIC SIGNS MAY BE OFFERED PROTEIN OF HIGHER BIOLOGICAL VALUES AND VITAMINS.
  • SOME CASES MAY REQUIRE SPECIFIC RX: PYOMETRA, HEARTWORM
  • COURSE OF ANTIBIOTICS
  • IMMUNOSUPPRESSIVE DRUGS
  • REGULAR MONITORING OF DEGREES OF PROTEINURIA
  • LEVELS OF UREA AND CREATININE
  • ANTIPLATELET THERAPY WITH ASPIRIN 5 MG /KG

INTERSTITIAL NEPHRITIS:

  • Rest
  • little exercise
  • The protein of high Biological Value
  • Drinking large amounts of quality water
  • Dilution of urine is necessary as e.coli is well in conc.urine
  • Antibiotics
  • Dextrose
  • B complex
  • Antacids
  • Corticosteroids
  • the pH of the urine should be adjusted with appropriate measures
Nephritis In Dogs

Note:

  • DURATION OF TREATMENT FOR URINARY INFECTION IS 10-14 DAYS
  • AMINOGLYCOSIDES CAUSES ACUTE TUBULAR NEPHROSIS
  • ANTIBIOTICS AMOXICILLIN/AMPICILLIN +CLOXACILIN CEFTRIAXONE SHOULD BE FOLLOWED.
  • ROBERTS TEST, MICROSCOPIC EXAMINATION, KIDNEY FUNCTION TEST HELPFUL IN DIAGNOSIS
  • RENAL HEALTH DIET OF ROYAL CANIN SHOULD BE GIVEN
  • LOW FAT AND SODIUM DIETS SHOULD BE GIVEN

Conclusion

Do regular deworming & Vaccination and check regularly Urination. Thank You.

Ajaykumarpala
Myself a Veterinary student. Hoping to be the best vet.

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Follow US On

Must Read

Drugs acting on Autonomic Nervous System Lecture Notes

0
lectures - Drugs acting on Autonomic Nervous SystemCompiled byDr. Nirbhay KumarAsstt. Professor & HeadDepartment of Veterinary Pharmacology & ToxicologyBihar Veterinary College, Bihar...

Latest Posts

Follow Us

504FansLike
314FollowersFollow
32FollowersFollow