fbpx
Thursday, November 19, 2020

In Dogs

on

0b3bfce0e1e285975f1506c35dbebc10?s=96&d=mm&r=g • Nephritis In Dogs
Ajaykumarpala
Myself a Veterinary student. Hoping to be the best vet.

Follow US On

(BRIGHTS DISEASE)

Definition

IS DEFINED AS INFLAMMATION OF KIDNEY ( RENAL CELLS ) CHARACTERISED BY RENAL COLIC AND WHICH RESULTS IN DELETERIOUS EFFECT ON HEALTH OF ANIMAL.
DOG, ONCE EFFECTED WITH , SEQUELAE IS DEATH.

Nephritis In Dogs

YOUR URINE VOLUME NOT ONLY ESTIMATES YOUR WATER INTAKE BUT ALSO KIDNEY FUNCTION

ONCE IT GET DIFFICULT TO URINATE , NEEDS HIGH CARE AND ATTENTION
KEEP IN MIND THAT MALE DOG USED TO URINATE BY LIFTQING ONE OF THE HIND LIMB AND PREFER TO URINATE IN A JET FASHION OVER ANY TREE WALL BITCHES URINATE IN SQUATTING POSTURE

Classification

IT IS OF TWO TYPES

  • SUPPURATIVE: PYEMIC-NEPHRITIS AND PYELO-NEPHRITIS
  • NON SUPPURATIVE: GLOMERULAR NEPHRITIS, TUBULAR NEPHRITIS AND INTERSTITIAL NEPHRITIS

IN CASE OF DOG OR PETS INTERSTITIAL AND GLOMERULAR ARE COMMONLY SEEN

ETIOLOGY :

Nephritis In Dogs
  •  FOOD AND WATER QUALITY
  • BACTERIA : E.COLI, LEPTOSPIRA
  • VIRUS: ICH
  • PARASITE: DIACTOPHYMA RENALE
  • OTHERS: METRITIS, PYOMETRA, BRONCHOPNEUMONIA, CYSTITIS, PROSTATITIS, CHRONIC PERITONITIS, AND CHRONIC INFECTIONS.
  • DRUGS: AMINOGLYCOSIDES, NEPHROTOXIC AGENTS, LEAD, ARSENATE, SULPHONAMIDE, MERCURY, AMPHOTERICIN B, AND PARACETAMOL

PATHOGENESIS :

GLOMERULAR NEPHRITIS:

  • INFECTION MAY SPREAD FROM DESCENDING AND ASCENDING SITE
  • STASIS OF URINE RESULTS IN ACCUMULATION OF MICROBES ALONG URINARY TRACT
  • THROUGH EMBOLI OR BLOOD BORNE , IT MAY RESULTS IN OCCURENCE OF NEPHRITIS
  • MAYBE DUE TO AUTOIMMUNE ACTIVITY

INTERSTITIAL NEPHRITIS:

  • INTERSTITIAL NEPHRITIS: VERY COMMON
  • CHRONIC FORM IS ALWAYS SEQULAE TO ACUTE FORM
  • PATHOGENESIS: PERIVASCULAR PERIGLOMERULAR INTERTUBULAR INFILTRATIONS,
  • KIDNEY PARENCHYMA UNDERGOES INFLAMMATORY CHANGES,
  • BLOCKS TUBULES OF KIDNEY WITH CELLULAR INFILTRATIONS
Nephritis In Dogs

CLINICAL SIGNS :

GLOMERULAR NEPHRITIS:

  • INFLAMMATION OF GLOMERULI LEADS TO CHRONIC RENAL FAILURE.
  • DULL AND DEPRESSED
  • SLIGHT RISE OF TEMPERATURE.
  • POLYDISPIA
  • PUFFY EYELIDS
  • MUSCLE WASTAGE
  • PROTEINURIA
  • VOMITING
  • AZOTEMIA
  • DRY SKIN COAT

INTERSTITIAL NEPHRITIS:

  • LACK OF APPETITE
  • POLYUREA AND POLYDISPIA
  • BREATH IS UNPLEASANT
  • TEETH, GUM, TONGUE COATED WITH REDDISH BROWN SCUM
  • ARCHING OF BACK AND STIFF GAIT
  • LUMBAR REGION PAIN
  • PULSE IS QUICK BOUNDING
  • CHRONIC CASES IT BECOME THIN AND EMACIATED
  • SIGNS OF DEHYDRATION
  • OCCASIONAL VOMITION
  • SIGNS OF URAEMIA
Nephritis In Dogs

DIAGNOSIS:

GLOMERULAR NEPHRITIS:

  • examination of Urine
  • PROTEINURIA
  • Proper history
  • Hematology: HYOPROTEINEMIA DUE TO HYPOALBUMINAEMIA, HYPERPROTEINAEMIA DUE TO HYPERGLOBINAEMIA, NORMOCYTIC NORMOCHROMIC ANAEMIA
  • BIOCHEMISTRY : HYPERCHOLESTEROLEMIA, HYPERPHOSPHATEMIA
  • AZOTEMIA
  • URINE STUDY : PROTEINURIA
  • PROTEIN INDEX : URINE = PROTEIN/ CREATININE RATIO>1 UPL = 1.42 + 22.12 × UP/C
  • RENAL BIOPSY
Nephritis In Dogs

INTERSTITIAL NEPHRITIS:

  • POLYUREA AND POLY DYSPIA
  • ACUTE: URINE HAVE HIGH SPECIFIC GRAVITY, ALBUMIN, RENAL EPITHELIAL CELLS, WBC, RBC, CASTS IN URINE.
  • CHRONIC: LOW SPECIFIC GRAVITY, LESS CELLULAR DEPOSITION.

DIFFERENTIAL DIAGNOSIS:

GLOMERULAR NEPHRITIS:

  • AMYLOIDOSIS: AMYLOID DEPOSITS WILL TAKE GREENISH APPEARANCE UPON STAINED WITH CONGORED
  • NEPHRITIS : LUMOY BUMPY DEPOSITS OF Immuno Globulins & COMPLEMENTS MAY BE OBSERVED PROLIFERATION OF MESANGIAL CELLS HYPERCELLULARITY IN BASEMENT MEMBRANE GLOMERULUS SCLEROSIS

INTERSTITIAL NEPHRITIS:

Chronic Interstitial nephritisDiabetes mellitusDiabetes insipidus
Kidney is affectedIslets of pancreaspost. pituitary gland
specific gravity is low highlow
Casts- very fewnilnil
Sugar- nilpresentnil
Uraemia- presentnilnil

Differentiation between glomerular and interstitial nephritis:

Nephritis In Dogs
ParameterGlomerular NephritisInterstitial Nephritis
Urine VolumeLowMore
Specific Gravitymorelow
Urinary sedimentcastsfew casts and WBC
Protein & UreaMoreLow
AnemiaModerateHigh

TREATMENT:

GLOMERULAR NEPHRITIS:

  • CASES WITHOUT NEPHROTIC SIGNS MAY BE OFFERED PROTEIN OF HIGHER BIOLOGICAL VALUES AND VITAMINS.
  • SOME CASES MAY REQUIRE SPECIFIC RX: PYOMETRA, HEARTWORM
  • COURSE OF ANTIBIOTICS
  • IMMUNOSUPPRESSIVE DRUGS
  • REGULAR MONITORING OF DEGREES OF PROTEINURIA
  • LEVELS OF UREA AND CREATININE
  • ANTIPLATELET THERAPY WITH ASPIRIN 5 MG /KG

INTERSTITIAL NEPHRITIS:

  • Rest
  • little exercise
  • The protein of high Biological Value
  • Drinking large amounts of quality water
  • Dilution of urine is necessary as e.coli is well in conc.urine
  • Antibiotics
  • Dextrose
  • B complex
  • Antacids
  • Corticosteroids
  • the pH of the urine should be adjusted with appropriate measures
Nephritis In Dogs

Note:

  • DURATION OF TREATMENT FOR URINARY INFECTION IS 10-14 DAYS
  • AMINOGLYCOSIDES CAUSES ACUTE TUBULAR NEPHROSIS
  • ANTIBIOTICS AMOXICILLIN/AMPICILLIN +CLOXACILIN CEFTRIAXONE SHOULD BE FOLLOWED.
  • ROBERTS TEST, MICROSCOPIC EXAMINATION, KIDNEY FUNCTION TEST HELPFUL IN DIAGNOSIS
  • RENAL HEALTH DIET OF ROYAL CANIN SHOULD BE GIVEN
  • LOW FAT AND SODIUM DIETS SHOULD BE GIVEN

Conclusion

Do regular deworming & Vaccination and check regularly Urination. Thank You.

0b3bfce0e1e285975f1506c35dbebc10?s=96&d=mm&r=g • Nephritis In Dogs
Ajaykumarpala
Myself a Veterinary student. Hoping to be the best vet.

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Follow US On

Must Read

Latest Posts

Follow Us

259FansLike
314FollowersFollow
23FollowersFollow